![]() ![]() Sonnymoon’s Anna Wise (who sang on Lamar’s good kid, m.A.A.d city) and Sa-Ra’s Taz Arnold also contribute vocals, the latter offering a “zoom zoom” adlib like the scatting from Afrika Bambaataa’s “Planet Rock.” Snoop then introduces the final verse as chatter from two people at a club. Produced by Rahki and Tommy Black, “Institutionalized” tells a thwarted Compton coming-of-age story, switching between characters to depict the struggles of one who’s “dazed and confused/Talented but still under the neighborhood ruse.” When Lamar closes his first verse, he introduces neo-soul impressionist Bilal, who sings the chorus - “shit don’t change until you get up and wash your ass” - from the perspective of the rapper’s grandma. “And right now, he’s mad.” Remember, Lamar named this song after the titular character of Roots. “It’s just expressing how he’s feeling at the moment,” Sounwave says. Lamar sounds desperate, even while referencing pop hits by Michael Jackson (“Life ain’t shit but a fat vagina/Screaming ‘Annie, are you OK,’”) and Parliament (“We want the funk!” - though it’s filtered through the 1994 track by West coast rapper Ahmad, who gets a writing credit). “This dick ain’t free,” he insists, surrounding the refrain with lines like “I need 40 acres and a mule/Not a 40-ounce and a pitbull.”Ī funky stomper with a Shaft-evoking call-and-response, “King Kunta” takes a darker turn once producer Mark “Sounwave” Spears cues an unsettling sample of “Get Nekkid” by Mausberg, the Compton-bred DJ Quik protege who was fatally shot at age 21. ![]() For his part, Lamar spits dense, nearly-spoken bars that come across like fast-rap version of the Last Poets. city” and one track on Glasper’s own Black Radio 2. ![]() Dre, in which he offers wisdom to Lamar on the fact that it’s easy to get success but more difficult to maintain it, a topic addressed in Lamar’s verses.ħ0 Greatest Music Documentaries of All TimeĬrossover jazz pianist Robert Glasper - whose Black Radio, an album featuring verses from Yasiin Bey, Erykah Badu and To Pimp a Butterfly collaborator Bilal, earned a 2013 R&B Grammy nomination - lays down hyperactive keys on this “interlude,” while Terrace Martin, himself the son of a jazz drummer, handles production, just as he did for Kurupt’s Streetlights, Kendrick’s “m.A.A.d. ![]() But the track’s biggest cameo comes in the form of a voice message from Dr. Clinton had been suggested as a collaborator by Flying Lotus, who produced “Wesley’s Theory” and additionally brought in bassist Thundercat, best known for his work alongside Lotus. The track also includes an appearance by Rock & Roll Hall of Famer George Clinton, whose group Parliament Lamar mentioned by name as an inspiration in his RS interview. With the song and film, Lockhart and Gardiner aimed to turn the meaning of “nigger” around, destroying its negative connotations. The album’s first song plays that out, opening with a sample from Boris Gardiner’s cheery manifesto of black pride “ Every Nigger Is a Star” off the soundtrack of the 1974 Calvin Lockhart-directed blaxploitation film of the same name. In his interview with Rolling Stone, Lamar reveals how influential Seventies funk was on To Pimp a Butterfly‘s sound. (The tweet has since been deleted.)įans, however, are enjoying the early release - a 16-song set that Lamar describes as “honest, fearful and unapologetic” in the cover story of the new issue of Rolling Stone. The appearance of Kendrick Lamar’s highly anticipated new album, To Pimp a Butterfly, on iTunes and Spotify Sunday night - more than a week before its scheduled March 23rd release date - apparently falls in the latter category. “Somebody’s gots 2 pay 4 this mistake,” Anthony Tiffith, the head of Lamar’s record label, Top Dawg Entertainment, tweeted in response. There are surprise releases and there are accidental releases. ![]()
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![]() ![]() In addition, CD33 is expressed on 85-90% of adult and pediatric cases of acute myeloid leukemia (Griffin, J. et al., (2006) Journal of Leukocyte Biology. Expression on subsets of mitogen or alloantigen-activated human T and natural killer (NK) cells has also been reported (Herna'ndez-Caselles T. 72:314-321 Simmons and Seed (1988) Immunol, 141:2797-2800), and selective expression was detected on blasts, promyelocytes and myelocytes in the hone marrow, and by monocytes in the peripheral blood (Griffit J. Siglec-3 (CD33) was cloned in 1988 (Peiper et al. The Siglec protein family is associated with multiple human disease including, autoimmunity, susceptibility to infection, multiple types of cancer including lymphoma, leukemia and acute myeloid leukemia, systemic lupus erythematosus, rheumatoid arthritis, neurodegenerative disorders, asthma, allergy, sepsis, chronic obstructive pulmonary disease, graft-versus-host disease, eosinophilia, and osteoporosis (Macauley S M. Certain Siglecs contain immunoreceptor tyrosine-based activating motif (ITAM) sequences in their cytoplasmic tails, which enable them to act as activating receptors and positive regulators of immune function through predicted recruitment of spleen tyrosine kinase (Syk) (Macauley S M. 343:2050-2056 and Von Gunten and Bochner (2008) Ann NY Acad Sci. 7:255-266 McMillan and Crocker (2008) Carbohydr Res. Most CD33-related Siglecs, including Siglec-3, contain one or more immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic tails, which enable them as inhibitory receptors and negative regulators of immune functions through recruitment of the tyrosine phosphatases SHP1 and SHP2 (Crocker et al. Each Siglec has a distinct preference for binding the diverse types of sialylated glycans that are found on the surface of mammalian cells (Crocker et al. Since cell membranes are rich in sialic acids, ligand binding by Siglecs can occur in cis and in trans, both affecting their functional properties. The binding sites to sialylated ligands have been mapped by co-crystal structures (Attrill et al., (2006) J. (2007) Nat Rev Immunol, 7:255-266 McMillan and Crocker (2008) Carbohydr Res. The sialic acid-binding region is located on the V-set Ig-like domain, which contains a two aromatic residues and one arginine motif highly conserved in all Siglecs (Crocker et al. Diversity in the Siglec ligands is generated by the addition of other neutral sugars and sialic acid in different linkages, and modification of sialic acid itself.įourteen Siglec proteins have been identified in humans and nine in mince that are comprised of 2-17 extracellular 1 g domains including an amino-terminal V-set domain that contains the sialic acid-binding site. Most gangliosides share a common lacto-ceramide core and one or more sialic acid residues. One potential binding target for Siglec proteins are gangliosides that is, glycolipids that consist of a ceramide linked to a sialylated glycan. CD33 is a member of the Siglec family of lectins that bind sialic acid residues of glycoproteins and glycolipids. ![]() CD33 expression is downregulated to low levels on peripheral granulocytes and resident macrophages and the protein was reported to be absent from astrocytes, oligodendrocytes, endothelial cells, and resting T cells (Griffin J D, et al., (1984) Leukemia Research Vol. ![]() Myeloid cell surface antigen CD33 precursor (CD33), also known as Siglec-3, is a type 1, immunoglobulin-like, transmembrane protein expressed on immune and hematopoietic cells, including immature and mature myeloid cells, dendritic cells, and microglial cells. This present disclosure relates to anti-CD33 antibodies and therapeutic uses of such antibodies. The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: a computer readable form (CRF) of the Sequence Listing (file name: 735022000100SEQLIST.TXT, date recorded: Dec. SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE ![]() 23, 2015, each of which is hereby incorporated by reference in its entirety. 11, 2016, which claims the benefit of U.S. national stage application of PCT/US2016/037109, filed internationally on Jun. ![]() ![]() ![]() Quake 3 Arena has basically become part of the furniture in the PC gaming scene. There was actually one official add-on pack released, Quake III: Team Arena (seen by some as an attempt to 'catch up' with the more diverse gameplay modes of Epic's Unreal Tournament), but this was met with a lukewarm critical response and poor sales. In spite of its technical merits, the game never spawned any modifications as popular as the phenomenal Counter-Strike, based on Half-Life. The engine further cemented John Carmack's position as the most important single PC games programmer, leading to him having an even greater involvement and influence in the 3D graphics hardware sector.Īs should be expected, the game is highly extensible, with the modding community using it over the years as a base for hundreds of projects including Quake 3 Fortress, Urban Terror, Freeze Tag, Reaction Quake 3, and countless others. The engine's main strengths however were its scalability, raw speed, and extremely robust network code. ![]() The lighting model, texture resolution and polygon count could all be ramped up substantially compared to the previous generation of shooters. The engine could also render 'true' curved surfaces allowing for all kinds of archways and domes, as well as volumetric fog and (very computationally expensive) portal surfaces, which could be used to make mirrors and teleport gates. Scripted shader effects allowed surfaces to be animated and multitextured in interesting ways, such as environment-mapped glass and fluttering banners. Quake 3 Arena was extremely graphically impressive at the time, and the ( OpenGL-based) engine is still occasionally used by new titles four years later (as I write this, Wolfenstein: Enemy Territory and Star Trek: Elite Force II have recently launched). Some arenas are little more than arrangements of metal platforms and bounce pads suspended in a black void. The levels are heavily stylised, with a mixture of biomechanical, sci-fi, medieval/ gothic and infernal architecture. ![]() The game is basically a collection of fairly small levels (arenas), and a pack of nicely animated character models with highly detailed skins. There are three game styles: deathmatch, team deathmatch, and capture the flag. The usual Quake powerups such as Quad Damage and Invisibility are still there, joined by some new ones such as Flight and Regeneration. Health and ammo collectibles are now represented by large glowing icons. This is especially handy for the railgun (almost identical to its Quake 2 counterpart), the weapon of choice among skilled players (although all of the weapons serve a useful purpose). There are no 'sniper scopes', players are allowed to zoom in their view at the press of a button, regardless of what weapon they are using. There are nine weapons, each of which represents a typical FPS weapon type ( mélee, machine gun, shotgun, rocket launcher, etc.). The controls, game rules and weapons have been tuned with the intention of making them as 'pure' as possible. Quake III Arena takes Quake 2's deathmatch mode as its starting point. Q3A is often criticised as being an 'engine looking for a game', although within the narrow gameplay boundaries it sets itself (straight deathmatch), it is easily the best implementation yet seen. This was seen as a daring move at the time, when online gaming was still seen as something of a novelty by many gamers. Q3A is almost entirely based around networked multiplayer gaming, with the single-player component being little more than a training mode against computer-controlled bots. Quake III Arena is another in a long line of graphically ambitious first-person shooters from the originators of the genre, Id Software. Platforms: PC CD-ROM ( Windows & Linux), Apple Macintosh, Sega Dreamcast, Sony Playstation 2 (as Quake III Revolution) ![]() ![]() ![]() The Support Package includes static "support libraries" that you can add to your Android application in order to use APIs that are either not available for older platform versions or that offer "utility" APIs that aren't a part of the framework APIs. The Android implementation of Khronos OpenGL Spec for the Google Android SDK.Īn alternative Android testing framework.Īn SDK for using Countly mobile analytics system in your Android app. This is built from 3c4f94d418b58d55d0facebf2bfbb362d4bf3bdd with an additional patch to support ECJ 4.2 and to strip out some unnecessary bundled libraries that we don't use for lint (to make the overhead smaller.)Īn Android library for Mixpanel Analytics This is a very small fork of lombok.ast as some Android tools needed a modification. Volley is a network library from Android source code. ![]() Library providing APIs to talk to Android devicesĪ set of FEST assertion helpers geared toward testing Android. Official Bugsnag notifier for Android applicationsĬommon library used by other Android tools libraries. ![]() SDK for integrating Android apps with Amplitude analytics.Ī library jar that provides APIs for testing Applications written for the Google Android Platform.Īndroid Library connecting social networks to your project easily, just add necessary Publishes a report of an Android application crash to Google docs (or some other end point).ĭroidKit Actors is simple actor model implementation for java and AndroidĪ library jar that provides APIs for Applications written for the Google Android Platform. The AspectJ weaver introduces advices to java classes The runtime needed to execute a program using AspectJ Maven Repository lists the POM file/libraries organized by topics and sub-topics. ![]() ![]() Set in 1920, the plot explores the period in their lives when both the freedom fighters choose to go into oblivion before they began the fight for their country. RRR is a fictional story about the friendship of two Indian revolutionaries, Alluri Sitarama Raju (Ram Charan) and Komaram Bheem (Jr NTR), who fought against the British Raj and Nizam of Hyderabad respectively. We will announce the new date very soon." ![]() They wrote, "Due to unforeseen circumstances we aren’t releasing the #RRRTrailer on December 3rd. The movie's official Twitter handle announced the postponement via a tweet. The makers earlier announced that the trailer of RRR will be released on December 3 but the reveal is pushed to a later date now. ![]() The filmmaker has promised to deliver an ultimate theatrical experience with this period-action drama. Is this a possibility? Only time will tell, but for now, WoW gamers can look forward to more exciting additions to their favorite online role playing game.'RRR' is the upcoming grandeur film in Indian cinema starring Jr NTR, Ram Charan, Alia Bhatt and directed by the master storyteller SS Rajamouli. The success of the initial film helped make way for an eventual sequel, and today, Blizzard Entertainment is hard at work creating new movies and television series in hopes of capturing the success of the first film yet again. With all of these potential new features and characters, it is easy to see why World of Warcraft 2 is fast becoming the biggest movie series launched in recent history. This means that fans of the film will have even more to look forward to. For instance, what was the purpose of adding the Blood Elves? How did the addition of Arthas (who is actually named Illidan Stormrage) into the mix happen? And now that the Lich King has returned, what does the future hold for the game? With the release of World of Warcraft: Wrath of the Lich King, fans of the game can look forward to more additions to the cast, more stories told through the in-game cinematic, and more overall changes. While some of these changes may be obvious to anyone who has played the game, others may be less so. In addition to a new race, there are also four new classes introduced in the game: Tauren, blood elves, dwarves, and gnomes, each with their own specializations and special skills. In previous WoW games, characters were allowed to take on any race, including the humans, elves, tauren, or orcs the latter races now belong to the Horde, led by their new chieftain, Thrall. What exactly has changed with the game world in this new movie? For one thing, the story takes place in the contested lands of Kalimdor, where Arthas has become the main adversary of the last hero to fight against the Lich King. It is the logical conclusion that a new game would be produced to celebrate the franchise’s 20th anniversary, and with such a long wait between movies, it seems like more hype is on the horizon. One thing is for sure, though, and that is that fans of the original game will want to see it regardless. There is also no official release date for the movie yet, but it is scheduled to hit theaters right after the summer’s end. With the new movie, gamers should expect more of the same, but at least one major change: there isn’t any familiar faces in the cast, at least at this point. So far, we’ve heard that the new movie will feature an all-star cast headed by Alexander Skarsgard and Djimon Hansu as Lorgar, Highlord Goren, and Magni, respectively. Based on the successful World of Warcraft movie series, Hordiss looks to continue the success of its predecessors while weaving a new tale in the process. Directed by Kenneth Branagh, the movie is set to premiere during the summer of 2021. In this new movie, however, the franchise will take the story in a different direction, focusing more on the game’s lore and the characters that will be seen in future games. We’ll just give some quick and general information on the Warcraft 2 itself, instead of diving into the more detailed aspects.Īs you may have guessed, Warcraft 2: Hordiss is based on the successful World of Warcraft game series. Since this is such a big production with multiple actors, plot lines and other details to take care of, we won’t be able to give our usual review. ![]() Warcraft 2 Movie is finally here? After months of build up, it finally has arrived and we here at Warcraft Reviews are ready to discuss it with our readers. ![]() ![]() ![]() Category books are published in sets of a predetermined number of titles each month. In this book, however, we’ll use the term category romances.Ĭategory romances are groupings of books that have certain elements in common for instance, they all involve a mystery as well as the romance, or they are all romantic comedy. ![]() The three terms are roughly synonymous, though series can also refer to a set of more closely related books (for instance, a trilogy in which each of three books features a different family member). Since then, the romance market has been ever changing, as new lines are brought out and foundering lines and subgenres are abandoned.Īt any given time there are at least twenty lines, series, or categories of romance novels (we’ll look at the different categories beginning on page 8). Unsuccessful lines and subgenres soon disappeared from the market. But not long after those other publishers launched their romance titles, they discovered that a commercially successful romance novel requires more than a simple handsome male meets cute female formula. Some of those changes were made in response to other publishers, who had noticed the success of the Harlequin/Mills & Boon machine and started bringing out their own romance novels. Radically different cover designs and distinctive brand names helped the reader more easily distinguish between the various styles of romances. Harlequin editorial offices in New York City and Toronto began acquiring new kinds of stories, written by new authors. Various types of romances began to split off from the long-established core. Contemporary, medical, and historical romances were all published as Harlequin Romance or Mills & Boon Romance.īut readers who gobbled up those original romances wanted even more variety, and authors wanted to stretch their wings with different kinds of stories-longer, spicier, more sensual, more confrontational, and including elements that just didn’t fit in the short, sweet, traditional package. Despite the lack of brand-name variety, however, the stories published under these imprints were widely divergent. (Appendix E includes a more complete list of current romance publishers.)įor many years, only one brand of romance novel existed, known generically in the United Kingdom as a Mills & Boon, and in North America as a Harlequin. Other major publishers of romance include Kensington, Avon, Bantam/Dell, Berkley/Jove, Dorchester, New American Library (NAL), Pocket Books, St. Since that time the two companies have functioned with relative independence under the Torstar corporate umbrella, though in recent years the line between the two houses has become less distinct. In the 1980s, Harlequin purchased its main rival, Silhouette Romance, from its founding publisher, Simon & Schuster. Though it began publishing American author Janet Dailey in the 1970s, Mills & Boon didn’t truly open up to other American authors until the early 1980s. In 1981, the firms became a division of the Torstar Corporation, a Canadian communications company.įor a number of years, Mills & Boon continued to be the sole acquiring editorial office, buying books mostly from British authors. Harlequin began setting up independent publishing offices around the world and started to publish romances in translation. The two firms merged in the early 1970s, with Mills & Boon becoming a branch office of Harlequin. In the late 1950s, the success of Mills & Boon romances was noted by a Canadian publishing company, Harlequin Books, which began publishing Mills & Boon books in North America as Harlequin Romances. ![]() As the years passed, romantic fiction outstripped other book sales by even greater margins, and eventually the firm dropped other types of books in order to concentrate on publishing romance novels. The firm soon realized that its hardcover romances, sold mostly to libraries, were more in demand than many of its regular titles. The publishing firm of Mills & Boon, established in 1908, brought out the work of such authors as Agatha Christie and Jack London-and also published romantic fiction. Though love and romance have long been a part of the literary world, the romance novel as we know it today originated in the early twentieth century in England. If the main focus of the story is the couple falling in love while they’re hiding out, it’s a romance novel. If the main focus of the story is the chase, what the bad guys are actually up to, and why they’re after the main character, the novel is general fiction. That depends on which elements of the story are emphasized. ![]() ![]() ![]() We’re always trying to make Apex Launcher better. Love Apex Launcher □? Rate us □ on Google Play. This app uses the Device Administrator permission for optional screen off/lock functionality.
![]() In his debut season, he scored 12 goals in 27 appearances and soon attracted the interest of European top clubs, like A.C. ![]()
![]() ![]() Nolan has also started a little store with some very cool accessories for your PS3 Eye. (2/2) Playstation 3 Eye Camera – Adding a Visible Light Blocking Filter and Tests with IR Light from Peau Productions on Vimeo.įor more on many, many topics – including distance calculators and other goodies – see Nolan’s blog: (1/2) Playstation 3 Eye Camera – Removing IR Blocking Filter from Peau Productions on Vimeo. Here’s how to hack that on the OEM-shipped lens. Like most webcams, the Sony normally detects visible light and blocks IR light. You can also easily track IR emitters or markers using this method. You might want light sources people can’t see that is, IR LEDs or broad-spectrum lights with filters. In this case, blocking visible light will eliminate the image of the projection (digital projectors don’t emit much IR-spectrum light), while infrared light can still provide tracking information. You might be doing tracking on top of a projection, as on many multitouch tables. There are various reasons you might want to use infrared light only. ![]() (Yes, I did in fact manage to cut myself the first time I tried. So I recommend the tutorial here even if only to figure out how to open the case. And it just looks, you know, like a gaming accessory. The case works fine when the camera is upright, but it’s a bit awkward, and it can’t sit horizontally for use in multitouch tables and installations and such. Whether you want to use IR or not, you will likely want to hack Sony’s case. Peau Productions has been one of the best sources for information on working with the PS3 Eye, and the man himself – Nolan – has done some great tutorials. Hack the Case, Remove the IR Blocking Filter You’ll want to trick out the PS3 Eye to make it really yours, with drivers, infrared-tracking capability, and a beautiful, new custom housing. Now, the hackers among you aren’t done yet. If you don’t already own a PS3 Eye, you should. Why choose the PS3 Eye over another webcam? Because it was built for CV applications, the camera performs well in variable lighting, has rock-solid, low-latency USB performance, and is capable of high framerates (60-75 fps at normal resolution or even 125-150 fps if you can sacrifice resolution, which might be okay for tracking). ![]() (The guy working at my local GameStop looked emotionally dejected when I told him I don’t actually own a PS3.) But thanks to community-developed, open-source drivers for all three platforms, the PS3 Eye has become a big choice for interactive applications, from tracking fingers and objects on tables to projection mapping and augmented reality. Sony intended it to be used with their flagship game console. It’s just US$40, and it’s your best ticket to creating your own computer vision and augmented reality projects, imagining stuff before big game console makers do. Photo ( CC) moonpie, who while I live in New York, lives in the original York. ![]() ![]() It provides you with markup and annotation tools that you can use to markup your PDF files easily and allow the recipient to know your thoughts. This PDF editor comes with optical character recognition technology that enables you to copy, edit and search scanned PDF documents very easily. Click with the left mouse button in the image and hold the button down. See also: Rotate Image 2.4Rotate Image Rotating an image allows to change the viewing angle on a three-dimensional object. ![]() This application enables you to increase the security of your PDF files by adding password and permission, digitally signing the PDF files, placing customs stamps to the files and redacting PDF. You use the pointer mode Navigate to move or rotate the image in the viewing area. 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It is also an ultimate PDF form creator and filler that allows you to fill out both interactive and non interactive forms without any difficulties. It supports multiple OCR languages, including English, French, Spanish, German, just to mention a few. If you have scanned PDF files that you want to edit or convert to other popular formats, rest assured that you will have an easy time dealing with them when you have this application. It also makes creating and converting of PDF files to other formats very easy. It features powerful editing and annotating features that are applicable to all kinds of PDF files. The best software program that you should consider if you want to markup PDF without any limitations or problems is PDFelement Pro. While Drawboard can help you a lot of when you want to create and amend PDF files, it has its limitations. PDFelement Pro for Mac - The Best Way to Markup PDF ![]() The Best Drawboard PDF Alternative to Markup PDF ![]() |
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